Tanı

MCAD eksikliği spesifik bir klinik tabloya sahip değildir. Tanıyı teyit edebilmek için birkaç test yapılmalıdır.
Bir metabolik kriz geçiren hastaların kanında ve idrarda bazı özel metabolitikler olacaktır.
Ancak, metabolik bir krizin oluşmasını beklemek zorunda kalmadan, enzimatik aktiviteyi ölçmek ve gen mutasyonları için hastanın DNA’sını kontrol etmek için bazı testler yapılabilir.

 

Yenidoğan tarama testi MCAD ve benzeri bozuklukların farkedilebileceği en etkin yöntemlerden birisidir.
Yenidoğan Tarama hakkında daha fazla bilgi için
MCAD eksikliği ciddi veya hafif formlarda ortaya çıkabilir. MCAD enziminin etkinliğinin daha fazla incelenmesi, MCAD eksikliğinin ne kadar ciddi olduğunu ve teşhisi doğrulayabileceğini gösterebilir.

Enzimatik aktivitenin ölçülmesi hakkında daha fazla bilgi için

Genetik test ACADM genindeki spesifik mutasyonlar araştırılabilir. Bu, MCAD teşhisini kesin olarak teyit edebilir ve mutasyonları tanımlayabilir.

Genetik araştırmalar hakkında daha fazla bilgi edinin

Daha önce teşhis konmamış olan bir hasta (örneğin yeni doğan taramasından geçmeyen), e metabolik bir kriz yaşayabilir. Bu semptomlara dayanarak teşhis de yapılabilir.
Metabolik kriz hakkında daha fazla bilgi edinin

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